Activation of gene expression by small RNA
Small regulatory RNAs (sRNAs) commonly act to downregulate gene expression. In bacteria, however, sRNAs have also been shown to activate genes by a variety of direct or indirect mechanisms. Several sRNAs (DsrA, GlmZ, RNAIII, RprA, RyhB, and Qrr) act as direct translational activators by an 'anti-antisense mechanism' in the 5′ mRNA region to liberate a sequestered ribosome binding site, while pairing of GadY sRNA to the 3′-end alters processing and increases stability of its target mRNA.…
Volume 12, Issue 6, 01 December 2009, Pp 674-682
Fröhlich, K.S. | Vogel, J.