Immunogenic cancer cell death: a key-lock paradigm
Physiological cell death, which occurs as a continuous byproduct of cellular turnover, is non-immunogenic or even tolerogenic, thereby avoiding autoimmunity. By contrast, cancer cell death elicited by radiotherapy and some chemotherapeutic agents such as anthracyclines is immunogenic. Recent data suggest that innate and cognate immune responses elicited by such anti-cancer agents are required for an optimal therapeutic outcome, underscoring the clinical relevance of immunogenic cell death. Here…
Volume 20, Issue 5, 01 October 2008, Pp 504-511
Tesniere, A. | Apetoh, L. | Ghiringhelli, F. | Joza, N. | Panaretakis, T. | Kepp, O. | Schlemmer, F. | Zitvogel, L. | Kroemer, G.